Benzenepropanal → HCID 21843576, compound

HRID 1941289Notes

Reaction equation

HRID 1941289 reaction equation
[C:1]([C:3]1[CH:14]=[CH:13][C:6]([CH2:7][N:8]2[CH:12]=[N:11][CH:10]=[N:9]2)=[CH:5][CH:4]=1)#[N:2].[Li]CCCC.[C:20]1([CH2:26][CH2:27][CH:28]=[O:29])[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>>[C:1]([C:3]1[CH:4]=[CH:5][C:6]([CH:7]([N:8]2[CH:12]=[N:11][CH:10]=[N:9]2)[CH:28]([OH:29])[CH2:27][CH2:26][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[CH:13][CH:14]=1)#[N:2]

Participants

4

Reactant 3

HCID 7707BenzenepropanalHCID 75376164-(1,2,4-Triazol-1-ylmethyl)benzonitrileHCID 178418339Butyllithium

Product 1

HCID 21843576HCID 21843576, compound

Procedure

1-[1-(4-cyanophenyl)-2-hydroxy-4-phenylbutyl]-1,2,4-triazole is prepared by the method described in Example 1 starting from 1-(4-cyano-benzyl)-1,2,4-triazole (2.0 g, 0.0108 mol), n-BuLi (0.0108 mol) and 3-phenylpropionaldehyde (1.74 g, 0.013 mol). The product is purified by flash chromatography.

Workup

  1. customThe product is purified by flash chromatography

Sources & evidence

ORD record
ord-a10a9e93c68346ab8ac14bf49ec11ec3
Source dataset
uspto-grants-1997_12
Patent number
US05703109

Reaction notes

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