Thionyl Chloride → HCID 21843579, compound

HRID 1941293Notes

Reaction equation

HRID 1941293 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9](O)[CH2:10][CH2:11][C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)=[CH:5][CH:4]=1)#[N:2].S(Cl)([Cl:22])=O>ClCCl>[Cl:22][CH:9]([C:6]1[CH:7]=[CH:8][C:3]([C:1]#[N:2])=[CH:4][CH:5]=1)[CH2:10][CH2:11][C:12]1[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 21843582HCID 21843582, compound

Product 1

HCID 21843579HCID 21843579, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1-(4-cyanophenyl)-3-(4-fluorophenyl)-1-propanol (3.43 g, 13 mmol) is dissolved in dichloromethane (20 ml). Thionylchloride (1.2 ml, 16 mmol) is added dropwise to the cooled solution and the mixture is stirred in room temperature for 2 hours. The mixture is washed with water, dried and the solvent is evaporated. The residue is used for the next step without further purification.

Workup

  1. washThe mixture is washed with water
  2. customdried
  3. customthe solvent is evaporated
  4. customThe residue is used for the next step without further purification

Sources & evidence

ORD record
ord-14ddc559df324c8b98f53953c03ebd18
Source dataset
uspto-grants-1997_12
Patent number
US05703109

Reaction notes

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