HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Propanoic acid, 2-methyl-3-(methylsulfonyl)-, (S)-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 22860484 | HCID 22860484 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | Propanoic acid, 2-methyl-3-(methylsulfonyl)-, (S)- | HCID 15814191 | 71.9% |
Reaction Steps
To 2.68 g of 2(S)-methyl-3-(methylsulfonyl)propionic acid t-butyl ester was added 20 mL of 4N hydrochlorid acid/dioxane and the mixture stirred at room temperature for 19 hours. The solvent was removed under reduced pressure to afford 2.18 g of crude product, which was recrystallized from ethyl acetate/hexane to yield 1.44g of 2(S)-methyl-3-(methylsulfonyl)propionic acid as white crystals, mp 81°-83° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05703076 |
| Source dataset | uspto-grants-1997_12 |
| ORD ID | ord-61652d433e2a48a792f005ef05938175 |
| Source note | uspto-grants-1997_12 |