D-1,4-Dithiothreitol → N-butanesulfonyl-tryptophanamide hydrochloride

Participants

Reaction Steps

To a solution of N-butanesulfonyl-(t-butoxycarbonyl)tryptophanamide (0.71 g, 1.68 mmol) and dithiothreitol (47 mg, 0.3 mmol) in 1,4-dioxane (4 ml) is added 4N HCl/1,4-dioxane (20 ml) at more temperature under nitrogen atmosphere and the mixture is stirred for 18 hours. The reaction mixture is concentrated in vacuo and the solid residue is washed with diethyl ether and dried to give N-butanesulfonyl-tryptophanamide hydrochloride.

Provenance & Evidence