Potassium Carbonate → HCID 67704053, compound

Participants

Reaction Steps

[αR(αR*,γR*,δS*)]-δ-Amino-γ-hydroxy-α-(1-methylethyl)-N-(2-methylpropyl)cyclohexanehexanamide (80 mg, 0.245 mmol), 5-bromo-2-methyl-2-pentene (44 mg, 0.27 mmol), and K2CO3 (250 mg) were dissolved in acetonitrile (10 mL) and stirred at RT for 24 h followed by heating at reflux under N2 for 8 h. The solvents were removed in vacuo. The residue was dissolved with CH2Cl2 and washed with water. The organic phase was dried over Na2SO4, filtered, and concentrated in vacuo. Silica gel chromatography (1:0:0 to 95:5:05 CH2Cl2 :MeOH:NH4OH gradient) of the concentrate afforded the title compound (42 mg, 42%) as a wax.

Provenance & Evidence