Methyl 4-nitrobutyrate → HCID 717394, compound

Participants

Reaction Steps

A mixture of 3-bromobenzaldehyde (82.20 g), methyl-4-nitrobutyrate (65.3 g) and ammonium acetate (68.5 g) in ethanol (400 ml), was heated to reflux for 18 hours. The solvent was removed in vacuo and the resultant mixture triturated with ethanol (400 ml) to give the title compound as a white solid (97.46 g). NMR (CDCl3) δ 2.30 (1H, m), 2.55 (3H, m), 4.70 (1H, m), 5.25 (1H, m), 6.7 (1H, s), 7.2-7.6 (4H, m).

Provenance & Evidence