Methyl 4-nitrobutyrate → HCID 717405, compound

Participants

Reaction Steps

Ammonium acetate (21.21 g), 4-trifluoromethylbenzaldehyde (19.61 ml) and methyl 4-nitrobutyrate (17.5 ml) in ethanol (150 ml) was stirred and heated under reflux for 3.5 h. After cooling to room temperature, an orange solid was formed which was filtered, washed with ethanol (2×100 ml) and dried in vacuo to give the title compound (30.56 g). Mass spectrometry. For C12H11F3N2O3, m/z 5.77 (2M+H+), 306 (M+NH4), 289 (MH+).

Provenance & Evidence