p-Fluoronitrobenzene → 2-(4-Nitrophenyl)-2H-tetrazole

Participants

Reaction Steps

A mixture of 1-fluoro-4-nitrobenzene (20 g), potassium carbonate (23.5 g) and 1H-tetrazole (12 g) in dimethylformamide (60 ml) was heated to 100° under nitrogen for 24 h. On cooling, the solvent was evaporated and the residue taken up in water, extracted with dichloromethane (4×100 ml), dried (Na2SO4) and evaporated to give an orange solid. This was purified by FCC (cyclohexane/ethyl acetate (3:1)) to give the title compound as a solid (6.5 g). T.l.c. (Cyclohexane/ethyl acetate (3:10), Rf 0.43.

Provenance & Evidence