HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuric Acid → 2-Hydroxy-5-tetrazol-2-yl-benzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Hexamethylenetetramine | HCID 4101 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 4-(2H-Tetrazol-2-yl)phenol | HCID 15760399 | — |
| Product | 2-Hydroxy-5-tetrazol-2-yl-benzaldehyde | HCID 10487900 | — |
Reaction Steps
Hexamethylenetetramine (5.6 g) was added to 4-tetrazol-2-yl-phenol (1.6 g) in trifluoroacetic acid (40 ml) and the mixture heated at 60° for 24 h. On cooling, the solution was poured into sulphuric acid (2N, 100 ml), extracted with ether (3×100 ml), dried (Na2SO4) and evaporated. The residue was purified by FCC (dichloromethane) to give the title compound as a yellow solid (930 mg). T.l.c. (Dichloromethane), Rf 0.56.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05703240 |
| Source dataset | uspto-grants-1997_12 |
| ORD ID | ord-85534c24397447ffa60b375b4f63d1db |
| Source note | uspto-grants-1997_12 |