Methyl Ethyl Ketone → HCID 21461386, compound

HRID 1941520Notes

Reaction equation

HRID 1941520 reaction equation
[Br:1][CH2:2][CH:3]1[O:12][CH2:11][CH:10]2[CH:6]([O:7][C:8]([CH3:14])([CH3:13])[O:9]2)[CH2:5][O:4]1.Br[CH2:16]C1OCC(O)C(O)CO1.C(C(C)=O)C>>[Br:1][CH2:2][CH:3]1[O:12][CH2:11][CH:10]2[CH:6]([O:7][C:8]([CH2:14][CH3:16])([CH3:13])[O:9]2)[CH2:5][O:4]1

Participants

4

Reactant 3

HCID 6569Methyl Ethyl KetoneHCID 21461382HCID 21461382, compoundHCID 21461387HCID 21461387, compound

Product 1

HCID 21461386HCID 21461386, compoundYield 82%

Procedure

4-Bromomethyl-9-ethyl-9-methyl-3,5,8, 10-tetraoxabicyclo[5.3.0]decane was prepared in a similar way to 4-bromomethyl-9,9-dimethyl-3,5,8, 10-tetraoxabicyclo [5.3.0]decane starting from 198.2 mmole (45 g ) of 2-bromomethyl-5,6-dihydroxy-1,3-dioxepane and 1.225 mol (88.3 g) of ethylmethylketone, fractional distillation giving 46 g (82% yield) from 95° to 100° C. (0.25 mbar).

Workup

  1. customgiving 46 g (82% yield) from 95° to 100° C. (0.25 mbar)

Sources & evidence

ORD record
ord-41aa75fbdaaa415ba1244467a7d2e77c
Source dataset
uspto-grants-1997_12
Patent number
US05703249

Reaction notes

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