Ethanolamine → HCID 21461441, compound

Temperature

100 °C

Triethylphosphite (16.6 g, 0.1 mmol), paraformaldehyde (3.0 g, 0.1 mmol) and ethanolamine (48.8 g, 0.8 mmol) was charged into a round bottom flask equipped with magnetic stir bar and reflux condenser. The reaction was heated to 100° C. for 16 h. Base hydrolysis of the intermediate esters was achieved by adding 2 equiv of NaOH (16 g of a 50% solution) and heating to 120° C. for 16 hours. The reaction was allowed to cool and was concentrated under vacuum. Methanol (100 mL) was added on the solvent was again removed under vacuum. This was repeated several times until a white solid formed the flask. The solid, which is a mixture of inorganic salts and sodium N-(2-hydroxyethyl) aminomethylphosphonate, was filtered and dried under vacuum to give 56% yield of sodium N-hydroxyethylaminomethylphosphonate. 31P-NMR obtained in D2O containing conc. HCl (pH=of sample is 0.7)δ=10.8 ppm. FAB-MS obtained in a glutathione/HCl matrix M+H=156.

1. customequipped with magnetic stir bar
2. temperaturereflux condenser
3. temperatureheating to 120° C. for 16 hours
4. temperatureto cool
5. concentrationwas concentrated under vacuum
6. additionMethanol (100 mL) was added on the solvent
7. customwas again removed under vacuum
8. customformed the flask
9. filtrationwas filtered
10. customdried under vacuum

ORD record

ord-41fbd2c3dd8e4e7f9bb4d7914b26b52f

Source dataset

uspto-grants-1997_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05703273