HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanolamine → N-(2-hydroxyethyl)aminomethylphosphonic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanolamine | HCID 700 | — |
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Triisopropyl phosphite | HCID 8304 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | N-(2-hydroxyethyl)aminomethylphosphonic acid | HCID 10942688 | 78% |
Reaction Steps
A solution of paraformaldehyde (4.0 g, 0.122 mole), ethanolamine (12 g, 0.2 mole), triisopropylphosphite (20.9 g, 0.1 mole) and 50 mL of isopropanol was stirred at 90° C. for 16 hours. The isopropanol was removed under vacuum and 50 mL of conc. HCl was added in one portion. The solution was heated at reflux for 6 hours after which time it was assayed by 31P-NMR. N-(2-Hydroxyethyl)aminomethylphosphonic acid was obtained in 78% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05703273 |
| Source dataset | uspto-grants-1997_12 |
| ORD ID | ord-76648cb7510e414997a36de3e68006b6 |
| Source note | uspto-grants-1997_12 |