HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → N-Boc-cis-4-hydroxy-L-proline methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 10707397 | HCID 10707397 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | N-Boc-cis-4-hydroxy-L-proline methyl ester | HCID 10752873 | 89.2% |
Reaction Steps
To a solution of (2S,4S)-1-t-butoxycarbonyl-4-formyloxy-2-methoxycarbonylpyrrolidine (5.12 g: 18.7 mmole) in methanol (51.0 ml), aqueous 1N-sodium hydroxide (18.7 ml) is added under ice cooling. The mixture is stirred at the same temperature for 20 minutes to give (2S,4S)-1-t-butoxycarbonyl-4-hydroxy-2-methoxycarbonylpyrrolidine (4.09 g). Yield: 89%. Colorless crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05703243 |
| Source dataset | uspto-grants-1997_12 |
| ORD ID | ord-885e9f8da1b24fcc87bac59a6fca3646 |
| Source note | uspto-grants-1997_12 |