HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tributylphosphine → 5-{4-[2-(3-Pyridylmethyleneaminooxy)ethoxy]benzyl}-thiazolidine-2,4-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tributylphosphine | HCID 13831 | — |
| Reactant | 5-(4-Hydroxybenzyl)-3-triphenylmethylthiazolidine-2,4-dione | HCID 2818126 | — |
| Reactant | 2-(3-Pyridylmethyleneaminooxy)ethanol | HCID 54040099 | — |
| Reactant | 1,1'-(Azodicarbonyl)dipiperazine | HCID 54471820 | — |
| Product | 5-{4-[2-(3-Pyridylmethyleneaminooxy)ethoxy]benzyl}-thiazolidine-2,4-dione | HCID 73847987 | 85.9% |
Reaction Steps
Following a procedure similar to that described in Example 3(a), but using 0.90 g of 2-(3-pyridylmethyleneaminooxy) ethanol (prepared as described in Preparation 5), 2.00 g of 5-(4-hydroxybenzyl)-3-tritylthiazolidine-2,4-dione, 1.32 ml of tributylphosphine and 1.23 g of 1,1'-(azodicarbonyl)dipiperazine, 1.37 g of the title compound were obtained as a crystalline powder, melting at 155°-157° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05703096 |
| Source dataset | uspto-grants-1997_12 |
| ORD ID | ord-d824ad53b36c43128a6548c3669f2ed5 |
| Source note | uspto-grants-1997_12 |