4'-Hydroxy-3',5'-dimethylacetophenone → 5-(4-{2-[1-(4-Hydroxy-3,5-dimethylphenyl)ethylideneaminooxy]ethoxy}benzyl)thiazolidine-2,4-dione

HRID 1941679Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1941679
[OH:1][C:2]1[C:7]([CH3:8])=[CH:6][C:5]([C:9](=O)[CH3:10])=[CH:4][C:3]=1[CH3:12].Cl.[NH2:14][O:15][CH2:16][CH2:17][O:18][C:19]1[CH:32]=[CH:31][C:22]([CH2:23][CH:24]2[S:28][C:27](=[O:29])[NH:26][C:25]2=[O:30])=[CH:21][CH:20]=1>>[OH:1][C:2]1[C:7]([CH3:8])=[CH:6][C:5]([C:9](=[N:14][O:15][CH2:16][CH2:17][O:18][C:19]2[CH:20]=[CH:21][C:22]([CH2:23][CH:24]3[S:28][C:27](=[O:29])[NH:26][C:25]3=[O:30])=[CH:31][CH:32]=2)[CH3:10])=[CH:4][C:3]=1[CH3:12]

Komponenten

3

Edukt 2

HCID 365814'-Hydroxy-3',5'-dimethylacetophenoneHCID 218339655-(4-[2-Aminooxyethoxy)benzyl]thiazolidine-2,4-dione hydrochloride

Produkt 1

HCID 1363959695-(4-{2-[1-(4-Hydroxy-3,5-dimethylphenyl)ethylideneaminooxy]ethoxy}benzyl)thiazolidine-2,4-dioneAusbeute 55,8 %

Versuchsvorschrift

Following a procedure similar to that described in Example 46, but using 0.22 g of 4'-hydroxy-3',5'-dimethylacetophenone and 0.40 g of 5-[4-(2-aminooxyethoxy)benzyl]thiazolidine-2,4-dione hydrochloride [prepared as described in Example 40(e)], 0.30 g of the title compound was obtained as an amorphous powder, melting at 53°-65° C. (softening point).

Quellen und Nachweise

ORD-Eintrag
ord-b134c7678ddb451a95c407e62c2e58f5
Quelldatensatz
uspto-grants-1997_12
Patentnummer
US05703096

Notizen zur Reaktion

Wird geladen…