HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1941765Generated: November 2, 2026
3-(Pyridin-3-yl)propan-1-amine → HCID 25264819, compound
https://huagongshe.com/reaction/1941765
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-(Pyridin-3-yl)propan-1-amine | HCID 13557523 | — |
| Reactant | (3S)-8-amino-9,10-difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carbonitrile | HCID 58346338 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 25264819 | HCID 25264819 | 15.1% |
Reaction Steps
To a solution of 5 (30 mg, 0.108 mmol) in 5 ml of DMSO, 29.5 mg (0.216 mmol) of 3-(pyridine-3-yl)propan-1-amine were added. The reaction mixture was heated to 120° C. for 3 h. The DMSO was removed under vacuo and the remaining solid was purified by preparative HPLC to give the title compound as a yellow solid (6.4 mg, 15% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08389514B2 |
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| Source dataset | uspto-grants-2013_03 |
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| ORD ID | ord-8d48d476738b493aa9fdd287fe6c35f9 |
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| Source note | uspto-grants-2013_03 |
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