Sodium Dithionite → HCID 58346343, compound

HRID 1941769Notes

Reaction equation

HRID 1941769 reaction equation
[F:1][C:2]1[C:3]([N+:22]([O-])=O)=[C:4]2[C:9]3=[C:10]([O:13][CH2:14][C:15]([CH3:17])([CH3:16])[N:8]3[CH:7]=[C:6]([C:18]([NH2:20])=[O:19])[C:5]2=[O:21])[C:11]=1[F:12].S(S([O-])=O)([O-])=O.[Na+].[Na+]>O.CO>[NH2:22][C:3]1[C:2]([F:1])=[C:11]([F:12])[C:10]2[O:13][CH2:14][C:15]([CH3:17])([CH3:16])[N:8]3[C:9]=2[C:4]=1[C:5](=[O:21])[C:6]([C:18]([NH2:20])=[O:19])=[CH:7]3

Participants

4

Reactant 2

HCID 24489Sodium DithioniteHCID 58346336HCID 58346336, compound

Product 1

HCID 58346343HCID 58346343, compoundYield 51%

Reagents, catalysts & solvents 1

HCID 22242641Methanol--water (1/1)Solvent

Procedure

To a suspension of 10 (6.3 g, 18.6 mmol) in a mixture of water/methanol 1/1 v/v (160 mL), sodium hydrosulfite (19.4 g, 116 mmol) was added and the suspension was refluxed for 5 h until all starting material was consumed. The product was collected by filtration while the mixture was still hot and washed with warm water. The solid was dried under vacuum to give 11 (2.92 g, 51% yield).

Workup

  1. additionwas added
  2. temperaturethe suspension was refluxed for 5 h until all starting material
  3. customwas consumed
  4. filtrationThe product was collected by filtration while the mixture
  5. washwashed with warm water
  6. customThe solid was dried under vacuum

Sources & evidence

ORD record
ord-c56fad1c13584068aaf3de48ed767f23
Source dataset
uspto-grants-2013_03
Patent number
US08389514B2

Reaction notes

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