HCID 58304243, compound → HCID 58304200, compound

Participants

Reaction Conditions

Reaction Steps

Under an inert atmosphere of argon a solution of (R)-4-(2-chloro-5-nitro-phenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine (intermediate X-3) (50 mg, 0.16 mmol) in tetrahydrofurane (1 ml) was treated at 0° C. with Raney nickel (50% in water, 0.07 ml). The mixture was stirred under hydrogen atmosphere at 0° C. for 15 minutes. The catalyst was filtered off and the filtrate was evaporated at reduced pressure to give the (R)-4-(5-amino-2-chloro-phenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine (42 mg, 93% of theory) as a yellow oil which was used without further purification. MS (ISP): m/z=276.1 [M+H]+.

Provenance & Evidence