3-Chloropyridine-2-carboxylic acid → HCID 53241711, 화합물

HRID 1941788노트

반응식

HRID 1941788 반응식
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([F:18])=[C:6]([C@:8]2([CH3:17])[C:13]([F:15])([F:14])[CH2:12][O:11][C:10]([NH2:16])=[N:9]2)[CH:7]=1.[Cl:19][C:20]1[C:21]([C:26](O)=[O:27])=[N:22][CH:23]=[CH:24][CH:25]=1>>[NH2:16][C:10]1[O:11][CH2:12][C:13]([F:14])([F:15])[C@:8]([C:6]2[CH:7]=[C:2]([NH:1][C:26]([C:21]3[C:20]([Cl:19])=[CH:25][CH:24]=[CH:23][N:22]=3)=[O:27])[CH:3]=[CH:4][C:5]=2[F:18])([CH3:17])[N:9]=1

참가 물질

3

반응물 2

HCID 8246323-Chloropyridine-2-carboxylic acidHCID 58304207(R)-4-(5-amino-2-fluoro-phenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine

생성물 1

HCID 53241711HCID 53241711, 화합물

실험 절차

The condensation of (R)-4-(5-amino-2-fluoro-phenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine (intermediate XI-1) and 3-chloro-pyridine-2-carboxylic acid following procedure I yielded the title compound as a colorless solid. MS (ISP): m/z=399.1 [M+H]+.

출처 및 근거

ORD 기록
ord-d66e5a2c415b4fd4b3156e35cc06c097
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08389513B2

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