HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Fluoromethoxypyridine-2-carboxylic acid → 5-Fluoromethoxy-pyridine-2-carboxylic acid [3-((R)-2-amino-5,5-difluoro-4,6,6-trimethyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Fluoromethoxypyridine-2-carboxylic acid | HCID 57475870 | — |
| Reactant | (R)-4-(5-amino-2-fluoro-phenyl)-5,5-difluoro-4,6,6-trimethyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine | HCID 58304251 | — |
| Product | 5-Fluoromethoxy-pyridine-2-carboxylic acid [3-((R)-2-amino-5,5-difluoro-4,6,6-trimethyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide | HCID 53240501 | — |
Reaction Steps
The condensation of (R)-4-(5-amino-2-fluoro-phenyl)-5,5-difluoro-4,6,6-trimethyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine (intermediate XI-2) and 5-fluoromethoxy-pyridine-2-carboxylic acid (CAS1174321-03-9, WO2009091016) following procedure I yielded the title compound as a white solid. MS (ISP): m/z=441.3 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08389513B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-6a5d3254f17640998e1d9b838ad66fc1 |
| Source note | uspto-grants-2013_03 |