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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1941816Generated: October 31, 2026

6-(cyclopropylmethoxy)nicotinic acid → HCID 53240607, compound

https://huagongshe.com/reaction/1941816

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-(cyclopropylmethoxy)nicotinic acidHCID 25116526—
Reactant(R)-4-(5-amino-2-fluoro-phenyl)-5,5-difluoro-4,6,6-trimethyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamineHCID 58304251—
ProductHCID 53240607HCID 53240607—

Reaction Steps

The condensation of (R)-4-(5-amino-2-fluoro-phenyl)-5,5-difluoro-4,6,6-trimethyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine (intermediate XI-2) and 6-cyclopropylmethoxy-nicotinic acid (CAS1019546-29-2, WO2008130320) following procedure I yielded the title compound as a light yellow solid. MS (ISP): m/z=463.2 [M+H]+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08389513B2
Source datasetuspto-grants-2013_03
ORD IDord-dfe773547a3442bfa603423081b7d286
Source noteuspto-grants-2013_03