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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1941825Generated: October 31, 2026

5-(Difluoromethoxy)picolinic acid → HCID 53240810, compound

https://huagongshe.com/reaction/1941825

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-(Difluoromethoxy)picolinic acidHCID 57475871—
Reactant(R)-4-(5-amino-2-fluoro-phenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamineHCID 58304207—
ProductHCID 53240810HCID 53240810—

Reaction Steps

The condensation of (R)-4-(5-amino-2-fluoro-phenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine (intermediate XI-1) and 5-difluoromethoxy-pyridine-2-carboxylic acid (CAS1174323-34-2, WO2009091016) following procedure I yielded the title compound as a white solid. MS (ISP): m/z=431.3 [M+H]+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08389513B2
Source datasetuspto-grants-2013_03
ORD IDord-f5aef21c6ad0453b8b677678e62a2ed6
Source noteuspto-grants-2013_03