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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1941826Generated: November 1, 2026

5-Fluoromethoxypyridine-2-carboxylic acid → HCID 53240811, compound

https://huagongshe.com/reaction/1941826

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-Fluoromethoxypyridine-2-carboxylic acidHCID 57475870—
Reactant(R)-4-(5-amino-2-fluoro-phenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamineHCID 58304207—
ProductHCID 53240811HCID 53240811—

Reaction Steps

The condensation of (R)-4-(5-amino-2-fluoro-phenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine (intermediate XI-1) and 5-fluoromethoxy-pyridine-2-carboxylic acid (CAS1174321-03-9, WO2009091016) following procedure I yielded the title compound as a colorless oil. MS (ISP): m/z=413.3 [M+H]+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08389513B2
Source datasetuspto-grants-2013_03
ORD IDord-d82cdbbdffa44a6a9ded095dc9412fb0
Source noteuspto-grants-2013_03