5-Chloro-2-picolinic acid → HCID 53241003, compound

HRID 1941838Notes

Reaction equation

HRID 1941838 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([C@:8]2([CH3:17])[C:13]([F:15])([F:14])[CH2:12][O:11][C:10]([NH2:16])=[N:9]2)[CH:5]=[CH:6][CH:7]=1.[Cl:18][C:19]1[CH:20]=[CH:21][C:22]([C:25](O)=[O:26])=[N:23][CH:24]=1>>[NH2:16][C:10]1[O:11][CH2:12][C:13]([F:15])([F:14])[C@:8]([C:4]2[CH:3]=[C:2]([NH:1][C:25]([C:22]3[CH:21]=[CH:20][C:19]([Cl:18])=[CH:24][N:23]=3)=[O:26])[CH:7]=[CH:6][CH:5]=2)([CH3:17])[N:9]=1

Participants

3

Reactant 2

HCID 27628725-Chloro-2-picolinic acidHCID 58304186HCID 58304186, compound

Product 1

HCID 53241003HCID 53241003, compound

Procedure

The condensation of (R)-4-(3-amino-phenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine (intermediate XI-4) and 5-chloro-pyridine-2-carboxylic acid following procedure I yielded the title compound as an off-white solid. MS (ISP): m/z=381.2 [M+H]+.

Sources & evidence

ORD record
ord-ea6d6eb1be9143b8982c5bc14333821d
Source dataset
uspto-grants-2013_03
Patent number
US08389513B2

Reaction notes

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