HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-METHYLPYRAZOLE-3-CARBOXYLIC ACID → HCID 53241208, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-METHYLPYRAZOLE-3-CARBOXYLIC ACID | HCID 5324580 | — |
| Reactant | (R)-4-(5-amino-2-fluoro-phenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine | HCID 58304207 | — |
| Product | HCID 53241208 | HCID 53241208 | — |
Reaction Steps
The condensation of (R)-4-(5-amino-2-fluoro-phenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine (intermediate XI-1) and 4-methyl-2H-pyrazole-3-carboxylic acid (CAS82231-51-4; B. Pelcman et al., WO2006032851) following procedure I yielded the title compound as a white solid. MS (ISP): m/z=368.1 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08389513B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-9dd0c1d3c413441497a9cb9fa014b512 |
| Source note | uspto-grants-2013_03 |