HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-1-(2,2-difluoroethyl)-1H-pyrazole-3-carboxylic acid → 4-Chloro-1-(2,2-difluoro-ethyl)-1H-pyrazole-3-carboxylic acid [3-((R)-2-amino-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-1-(2,2-difluoroethyl)-1H-pyrazole-3-carboxylic acid | HCID 19622801 | — |
| Reactant | (R)-4-(5-amino-2-fluoro-phenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine | HCID 58304207 | — |
| Product | 4-Chloro-1-(2,2-difluoro-ethyl)-1H-pyrazole-3-carboxylic acid [3-((R)-2-amino-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide | HCID 53241299 | — |
Reaction Steps
The condensation of (R)-4-(5-amino-2-fluoro-phenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine (intermediate XI-1) and 4-chloro-1-(2,2-difluoro-ethyl)-1H-pyrazole-3-carboxylic acid following procedure I yielded the title compound. MS (ISP): m/z=452.1 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08389513B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-6afe359183f4413c918a24687aea0207 |
| Source note | uspto-grants-2013_03 |