Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1941865Generated: October 30, 2026

HCID 57475884, compound → HCID 67234255, compound

https://huagongshe.com/reaction/1941865

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 57475884HCID 57475884—
Reactant(R)-4-(5-amino-2-fluoro-phenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamineHCID 58304207—
ProductHCID 67234255HCID 67234255—

Reaction Steps

The condensation of (R)-4-(5-amino-2-fluoro-phenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine (intermediate XI-1) and 2-fluoromethyl-oxazole-4-carboxylic acid following procedure I yielded the title compound after purification by preparative HPLC as a white solid. MS (ISP): m/z=387.1 [M+H]+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08389513B2
Source datasetuspto-grants-2013_03
ORD IDord-60380b0340854ad890610704eb1ffaf4
Source noteuspto-grants-2013_03