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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1941867Generated: October 30, 2026

2-Furancarboxylic acid → HCID 53241491, compound

https://huagongshe.com/reaction/1941867

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Furancarboxylic acidHCID 6919—
Reactant(R)-4-(5-amino-2-fluoro-phenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamineHCID 58304207—
ProductHCID 53241491HCID 53241491—

Reaction Steps

The condensation of (R)-4-(5-amino-2-fluoro-phenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine (intermediate XI-1) and furan-2-carboxylic acid following procedure I yielded the title compound after purification by preparative HPLC. MS (ISP): m/z=354.4 [M+H]+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08389513B2
Source datasetuspto-grants-2013_03
ORD IDord-1ac8bd8643bc4cb99f6b07809717aac3
Source noteuspto-grants-2013_03