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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1941868Generated: October 31, 2026

5-Nitro-2-Furoic Acid → HCID 53241492, compound

https://huagongshe.com/reaction/1941868

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-Nitro-2-Furoic AcidHCID 12577—
Reactant(R)-4-(5-amino-2-fluoro-phenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamineHCID 58304207—
ProductHCID 53241492HCID 53241492—

Reaction Steps

The condensation of (R)-4-(5-amino-2-fluoro-phenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine (intermediate XI-1) and 5-nitro-furan-2-carboxylic acid (CAS645-12-5) following procedure I yielded the title compound after purification by preparative HPLC. MS (ISP): m/z=399.3 [M+H]+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08389513B2
Source datasetuspto-grants-2013_03
ORD IDord-3f8952eb5e6f4b0f883da3ebd34fed80
Source noteuspto-grants-2013_03