HuagongsheHuagongshe Chemistry Print Report · For research reference only
N,N-dimethyl-1-(3-nitrophenyl)methanesulfonamide → 1-(3-aminophenyl)-N,N-dimethylmethanesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N,N-dimethyl-1-(3-nitrophenyl)methanesulfonamide | HCID 28632733 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-(3-aminophenyl)-N,N-dimethylmethanesulfonamide | HCID 43256215 | 96% |
Reaction Steps
(3-Nitrophenyl)-N,N-dimethylmethanesulfonamide (2.32 g, 9.5 mmol) was hydrogenated over Raney nickel (0.5 g) in methanol at 50° C. and 70 psi for 4 h, then catalyst was filtered off, washed with warm methanol, combined filtrates were evaporated to give 1.95 g (96%) of (3-aminophenyl)-N,N-dimethylmethanesulfonamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08389521B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-4b4947fc59d04593a0abb3be94be815d |
| Source note | uspto-grants-2013_03 |