HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1941910Generated: November 3, 2026
4-Chloro-6-(2-methoxyphenyl)pyrimidine → C-{3-[6-(2-methoxy-phenyl)-pyrimidin-4-ylamino]-phenyl}-N,N-dimethyl-methanesulfonamide
https://huagongshe.com/reaction/1941910
Participants
| Role | Name | HCID | Charge |
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| Reactant | 4-Chloro-6-(2-methoxyphenyl)pyrimidine | HCID 15206835 | — |
| Reactant | 1-(3-aminophenyl)-N,N-dimethylmethanesulfonamide | HCID 43256215 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | C-{3-[6-(2-methoxy-phenyl)-pyrimidin-4-ylamino]-phenyl}-N,N-dimethyl-methanesulfonamide | HCID 25104563 | — |
Reaction Steps
A mixture of (3-aminophenyl)-N,N-dimethylmethanesulfonamide (0.107 g, 0.50 mmol) and 4-chloro-6-(2-methoxyphenyl)-pyrimidine (0.110 g, 0.10 mmol) in DMFA (3 mL) was stirred at 80° C. till the reaction completion (TLC control), then concentrated in vacuo and the residue was recrystallized from isopropanol to give C-{3-[6-(2-methoxy-phenyl)-pyrimidin-4-ylamino]-phenyl}-N,N-dimethyl-methanesulfonamide (Reference compound 1)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08389521B2 |
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| Source dataset | uspto-grants-2013_03 |
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| ORD ID | ord-0c9461580bce4eaf9ca2865697334144 |
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| Source note | uspto-grants-2013_03 |
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