HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(3-Methoxy-propyl)-C-(3-nitro-phenyl)-methanesulfonamide → C-(3-amino-phenyl)-N-(3-methoxy-propyl)-methanesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(3-Methoxy-propyl)-C-(3-nitro-phenyl)-methanesulfonamide | HCID 59411197 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | C-(3-amino-phenyl)-N-(3-methoxy-propyl)-methanesulfonamide | HCID 43256757 | 50.2% |
Reaction Steps
N-(3-Methoxy-propyl)-C-(3-nitro-phenyl)-methanesulfonamide (0.31 g, 1.08 mmol) was hydrogenated over Raney nickel (0.05 g) in methanol at 50° C. and 70 psi for 4 h. Then, the catalyst was filtered off, washed with warm methanol, and the combined filtrates were evaporated to give 0.14 g (50%) of C-(3-amino-phenyl)-N-(3-methoxy-propyl)-methanesulfonamide
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08389521B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-db00cdd34a224693b4b924da31888435 |
| Source note | uspto-grants-2013_03 |