Dimethylformamide diethylacetal → HCID 67456455, compound

HRID 1942016Notes

Reaction equation

HRID 1942016 reaction equation
[CH2:1]([O:3][C:4](=[O:12])[CH2:5][N:6]1[CH:10]=[C:9]([CH3:11])[N:8]=[CH:7]1)[CH3:2].C(O[CH:16](OCC)[N:17]([CH3:19])[CH3:18])C>>[CH2:1]([O:3][C:4](=[O:12])[C:5]([N:6]1[CH:10]=[C:9]([CH3:11])[N:8]=[CH:7]1)=[CH:16][N:17]([CH3:19])[CH3:18])[CH3:2]

Participants

3

Reactant 2

HCID 70913Dimethylformamide diethylacetalHCID 237336Ethyl (4-methyl-1H-imidazol-1-yl)acetate

Product 1

HCID 67456455HCID 67456455, compound

Procedure

310 mg (1.5 mmol, 80% purity) of the compound from Example 34A and 0.5 ml (434 mg, 3.0 mmol) dimethylformamide diethyl acetal are stirred at a bath temperature of 100° C. for 16 h. For working up, the cooled reaction solution is concentrated on a rotary evaporator and the residue is dried in vacuo. The product is obtained as a 3:2 mixture of the two regioisomers and is further reacted as such.

Workup

  1. customthe cooled reaction solution
  2. concentrationis concentrated on a rotary evaporator
  3. customthe residue is dried in vacuo
  4. customThe product is obtained as a 3:2 mixture of the two regioisomers
  5. customis further reacted as such

Sources & evidence

ORD record
ord-5aed60d98ce2458ba7743fde019440e7
Source dataset
uspto-grants-2013_03
Patent number
US08389520B2

Reaction notes

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