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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1942041Generated: November 2, 2026

Hydrochloric Acid → 2-[5-(2,2-Dimethylpropoxy)pyridin-2-yl]-4-(1H-imidazol-1-yl)-1,2-dihydro-3H-pyrazol-3-one hydrochloride

https://huagongshe.com/reaction/1942041

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
Reactant2-[5-(2,2-Dimethylpropoxy)pyridin-2-yl]-4-(1H-imidazol-1-yl)-1,2-dihydro-3H-pyrazol-3-oneHCID 59603695—
Solvent1,4-DioxaneHCID 31275—
Product2-[5-(2,2-Dimethylpropoxy)pyridin-2-yl]-4-(1H-imidazol-1-yl)-1,2-dihydro-3H-pyrazol-3-one hydrochlorideHCID 67455029—

Reaction Steps

5 ml of a 4 N solution of hydrogen chloride in dioxane are added to 200 mg (0.638 mmol) of the compound from Example 92 and the mixture is stirred at RT for 30 min The solid is subsequently filtered off, washed once with dioxane and twice with tert-butyl methyl ether and subsequently dried under a high vacuum.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08389520B2
Source datasetuspto-grants-2013_03
ORD IDord-ead6475a5d074a8a852155532dbfc6c5
Source noteuspto-grants-2013_03