反应详情

(rac)-5,7-Difluoro-6-[1-(6-piperazin-1-yl-imidazo[1,2-b]pyridazin-3-yl)-ethyl]-quinoline (Example 6, 35 mg, 0.089 mmol) was dissolved in pyridine (0.89 mL) and methyl chloroformate (0.010 mL, 0.133 mmol) was added. The RM was stirred at RT for 1.5 h. The mixture was concentrated and the residue was purified by flash chromatography and afforded the title compound as a beige foam (tR 3.70 min (conditions 1), MH+=453).

1. concentrationThe mixture was concentrated
2. customthe residue was purified by flash chromatography