HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Fluoride → HCID 50914774, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Fluoride | HCID 522689 | — |
| Reactant | (Rac)-6-[1-(6-chloro-imidazo[1,2-b]pyridazin-3-yl)-ethyl]-5,7-difluoro-quinoline | HCID 58147541 | — |
| Reactant | 1-phenyl-2-piperazinone trifluoroacetate | HCID 67085055 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | HCID 50914774 | HCID 50914774 | — |
Reaction Conditions
| Temperature | 180 °C |
|---|
Reaction Steps
(rac)-6-[1-(6-Chloro-imidazo[1,2-b]pyridazin-3-yl)-ethyl]-5,7-difluoro-quinoline (Intermediate C, 50 mg, 0.145 mmol), KF (84 mg, 1.450 mmol), 1-phenylpiperazin-2-one TFA salt (133 mg, 0.435 mmol) were suspended in NMP (483 μL). The RM was stirred at 180° C. for 5 h. The mixture was purified by preparative UPLC with acetonitrile and water (+0.1% TFA) The fractions were collected and acetonitrile was removed. It was taken up with MeOH and passed through an SPE cartridge of PL-HCO3 MP from polymer lab. The solvent was removed and a brown solid was obtained (tR 1.0 min (conditions 4), MH+=485).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08389526B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-302c5fe622514274989fb32b5309cec8 |
| Source note | uspto-grants-2013_03 |