1-Acetylpiperazine → HCID 50914923, compound

HRID 1942085Notes

Reaction equation

HRID 1942085 reaction equation
Cl[C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([C@H:11]([C:13]3[CH:14]=[C:15]4[C:19](=[CH:20][C:21]=3[F:22])[N:18]([CH3:23])[N:17]=[CH:16]4)[CH3:12])=[CH:9][N:10]=2)[N:7]=1.[C:24]([N:27]1[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1)(=[O:26])[CH3:25]>>[F:22][C:21]1[CH:20]=[C:19]2[C:15]([CH:16]=[N:17][N:18]2[CH3:23])=[CH:14][C:13]=1[C@@H:11]([C:8]1[N:6]2[N:7]=[C:2]([N:30]3[CH2:31][CH2:32][N:27]([C:24](=[O:26])[CH3:25])[CH2:28][CH2:29]3)[CH:3]=[CH:4][C:5]2=[N:10][CH:9]=1)[CH3:12]

Participants

3

Reactant 2

HCID 837951-AcetylpiperazineHCID 58147538HCID 58147538, compound2×

Product 1

HCID 50914923HCID 50914923, compound

Procedure

The title compound was prepared analogy to Example 38 using 6-chloro-3-[(S)-1-(6-fluoro-1-methyl-1H-indazol-5-yl)-ethyl]-imidazo[1,2-b]pyridazine (Intermediate E) (50 mg, 0.153 mmol) and 1-acetylpiperazine (39.2 mg, 0.306 mmol) (tR 3.67 min (conditions 5), MH+=421, 1H-NMR in DMSO-d6: 7.93 (s, 1H); 7.81 (d, 1H); 7.52 (d, 1H); 7.50 (s, 1H); 7.47 (d, 1H); 4.75 (m, 1H); 3.95 (s, 3H); 3.42 (m, 6H); 2.00 (s, 3H); 1.70 (d, 3H)).

Sources & evidence

ORD record
ord-f3b9367daefc4c1ebba1dc2fa125b32f
Source dataset
uspto-grants-2013_03
Patent number
US08389526B2

Reaction notes

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