1-Acetylpiperazine → HCID 50912877, compound

Participants

Reaction Steps

The title compound was prepared in analogy to Example 38 using (rac)-6-[1-(6-chloro-imidazo[1,2-b]pyridazin-3-yl)-ethyl]-7-fluoro-quinoline (Intermediate K, 50 mg, 0.153 mmol) and 1-acetylpiperazine (39.2 mg, 0.306 mmol) (tR 3.33 min (conditions 5), MH+=419, 1H-NMR in DMSO-d6: 8.83 (d, 1H); 8.30 (d, 1H); 7.83 (d, 1H); 7.74 (d, 1H); 7.56 (s, 1H); 7.44 (m, 1H); 7.10 (d, 1H); 4.87 (m, 1H); 3.37 (m, 8H); 1.98 (s, 3H); 1.78 (d, 3H)).

Provenance & Evidence