Piperazin-2-one → HCID 50913159, compound

HRID 1942097Notes

Reaction equation

HRID 1942097 reaction equation
Cl[C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([CH2:11][C:12]3[C:13]([F:23])=[C:14]4[C:18](=[CH:19][C:20]=3[F:21])[N:17]([CH3:22])[N:16]=[CH:15]4)=[CH:9][N:10]=2)[N:7]=1.[NH:24]1[CH2:29][CH2:28][NH:27][CH2:26][C:25]1=[O:30]>>[F:23][C:13]1[C:12]([CH2:11][C:8]2[N:6]3[N:7]=[C:2]([N:27]4[CH2:28][CH2:29][NH:24][C:25](=[O:30])[CH2:26]4)[CH:3]=[CH:4][C:5]3=[N:10][CH:9]=2)=[C:20]([F:21])[CH:19]=[C:18]2[C:14]=1[CH:15]=[N:16][N:17]2[CH3:22]

Participants

3

Reactant 2

HCID 231360Piperazin-2-oneHCID 581475346-chloro-3-((4,6-difluoro-1-methyl-1H-indazol-5-yl)methyl)imidazo[1,2-b]pyridazine

Product 1

HCID 50913159HCID 50913159, compound

Procedure

The title compound was prepared in analogy to Example 52 using 6-chloro-3-((4,6-difluoro-1-methyl-1H-indazol-5-yl)methyl)imidazo[1,2-b]pyridazine (Intermediate T, (100 mg, 0.300 mmol) and piperazin-2-one (90 mg, 0.899 mmol) (tR 3.47 min (conditions 4), MH+=398, 1H-NMR in DMSO-d6: 8.13 (s, 1H); 8.11 (s, 1H); 7.81 (d, 1H); 7.45 (d, 1H); 7.27 (s, 1H); 7.09 (d, 1H), 4.27 (s, 2H); 3.98 (m, 5H); 3.67 (m, 2H), 3.29 (m, 2H)).

Sources & evidence

ORD record
ord-35bf4db7d71e432a9f0e624e1e2abf04
Source dataset
uspto-grants-2013_03
Patent number
US08389526B2

Reaction notes

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