참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 4-Bromoaniline | HCID 7807 | — |
| 반응물 | Pyrrolidine | HCID 31268 | — |
| 반응물 | Sodium Nitrite | HCID 23668193 | — |
| 용매 | Hydrochloric Acid | HCID 313 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Potassium Hydroxide | HCID 14797 | — |
| 생성물 | HCID 178419396 | HCID 178419396 | 46.2% |
반응 단계
To a 0° C. solution of 4-bromo aniline (133, 10 g, 58.1 mmol) in concentrated HCl (11.7 mL) was added dropwise a solution of NaNO2 (4 g, 57.9 mmol) in H2O (5 mL). The reaction was then stirred for an additional 10 min. at 0° C. after the addition. The resulting diazonium salt solution was added at once to a solution of pyrrolidine (4.54 g, 63.9 mmol) in 1M KOH (50 mL). The reaction mixture was stirred for 30 min at 0-10° C. The resulting precipitate was then filtered and recrystallized from absolute ethanol (50 mL) to give compound 134 (6.8 g, 46.2%) as light yellow crystals.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08389529B2 |
|---|
| 출처 데이터셋 | uspto-grants-2013_03 |
|---|
| ORD ID | ord-4414ec80b07347bab880f4b89fd67109 |
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| 출처 메모 | uspto-grants-2013_03 |
|---|
