HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3-Diethyl 2-oxopropanedioate → HCID 68473442, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3-Diethyl 2-oxopropanedioate | HCID 69105 | — |
| Reactant | 4-(3-Fluoro-4-methylphenyl)-3-oxo-3,4-dihydropyrido[2,3-b]pyrazine-2-carboxylic acid | HCID 67531117 | — |
| Reactant | HCID 67531613 | HCID 67531613 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 68473442 | HCID 68473442 | 89% |
Reaction Steps
19.8 g (0.1 mol) of N-(6-methylpyridine-2-yl)benzene-1,2-diamine was dissolved in toluene (100 ml), and 19.0 g (0.11 mol) of diethyl ketomalonate and 57.1 g of 4 A molecular sieve were added thereto. The solution was heated to reflux for 3 hours while removing water using a Dean-Stark apparatus. Reaction mixture was filtered, and the filtrate was concentrated under reduced pressure to obtain 27.2 g (yield: 89%) of ethyl 1-(6-methylpyridine-2-yl)-2-oxo-1,2-dihydroquinoxaline-3-carboxylate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08389523B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-0e88a658edad4c3ca24efb3f7853d644 |
| Source note | uspto-grants-2013_03 |