2-Methanesulfonyl-5-phenylethynyl-pyrimidine → HCID 178521603, compound

HRID 1942175Notes

Reaction equation

HRID 1942175 reaction equation
CS([C:5]1[N:10]=[CH:9][C:8]([C:11]#[C:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:7][N:6]=1)(=O)=O.Cl.[NH2:20][C@@H:21]1[CH2:26][CH2:25][C@H:24]([OH:27])[CH2:23][CH2:22]1>>[C:13]1([C:12]#[C:11][C:8]2[CH:7]=[N:6][C:5]([NH:20][C@@H:21]3[CH2:26][CH2:25][C@H:24]([OH:27])[CH2:23][CH2:22]3)=[N:10][CH:9]=2)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 575167582-Methanesulfonyl-5-phenylethynyl-pyrimidineHCID 178479277HCID 178479277, compound

Product 1

HCID 178521603HCID 178521603, compound

Procedure

The title compound, MS: m/e=294.2 (M+H+), can be prepared in accordance with the general method of example 1, step 3 from 2-methanesulfonyl-5-phenylethynyl-pyrimidine (example 1, step 2) and cis-4-aminocyclohexanol hydrochloride.

Sources & evidence

ORD record
ord-1605b4d05b9e43acb4952d7ecf1a0f8c
Source dataset
uspto-grants-2013_03
Patent number
US08389536B2

Reaction notes

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