4-Methylcyclohexylamine → HCID 178461303, compound

HRID 1942183Notes

Reaction equation

CS([C:5]1[N:10]=[CH:9][C:8]([C:11]#[C:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:7][N:6]=1)(=O)=O.[CH3:19][CH:20]1[CH2:25][CH2:24][CH:23]([NH2:26])[CH2:22][CH2:21]1>>[CH3:19][C@H:20]1[CH2:25][CH2:24][C@H:23]([NH:26][C:5]2[N:10]=[CH:9][C:8]([C:11]#[C:12][C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[CH:7][N:6]=2)[CH2:22][CH2:21]1

Participants

Reactant 2

HCID 806044-Methylcyclohexylamine

HCID 575167582-Methanesulfonyl-5-phenylethynyl-pyrimidine

Product 1

HCID 178461303HCID 178461303, compound

Procedure

The title compound, white solid, MS: m/e=292.2 (M+H+), can be prepared in accordance with the general method of example 1, step 3 from 2-methanesulfonyl-5-phenylethynyl-pyrimidine (example 1, step 2) and 4-methyl-cyclohexylamine.

Sources & evidence

ORD record: ord-161dd156b2d84067bcef1fd88f5851f4
Source dataset: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08389536B2

Reaction notes

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