HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Methyl-3-oxetanemethanol → 2-(3-Methyl-oxetan-3-ylmethoxy)-5-phenylethynyl-pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Methyl-3-oxetanemethanol | HCID 137837 | — |
| Reactant | 2-Methanesulfonyl-5-phenylethynyl-pyrimidine | HCID 57516758 | — |
| Product | 2-(3-Methyl-oxetan-3-ylmethoxy)-5-phenylethynyl-pyrimidine | HCID 52917264 | — |
Reaction Steps
The title compound, yellow solid, MS: m/e=281.1 (M+H+), can be prepared in accordance with the general method of example 1, step 3 from 2-methanesulfonyl-5-phenylethynyl-pyrimidine (example 1, step 2) and (3-methyl-oxetan-3-yl)-methanol by using Cs2CO3 as base and dioxane as solvent for 16 hours at 100° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08389536B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-3be123aed1ef4c68b756145d5660fb25 |
| Source note | uspto-grants-2013_03 |