Phenylacetylene → (5-Phenylethynyl-pyridin-2-yl)-methanol

HRID 1942193Notes

Reaction equation

Br[C:2]1[CH:3]=[CH:4][C:5]([CH2:8][OH:9])=[N:6][CH:7]=1.[C:10]1([C:16]#[CH:17])[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>>[C:10]1([C:16]#[C:17][C:2]2[CH:3]=[CH:4][C:5]([CH2:8][OH:9])=[N:6][CH:7]=2)[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

Participants

Reactant 2

HCID 10821Phenylacetylene

HCID 5200169(5-Bromopyridin-2-yl)methanol

Product 1

HCID 57517077(5-Phenylethynyl-pyridin-2-yl)-methanol

Procedure

The title compound, light brown solid, MS: m/e=210.2 (M+H+), can be prepared in accordance with the general method of example 1, step 1 from (5-bromopyridin-2-yl)methanol and phenylacetylene.

Sources & evidence

ORD record: ord-980232bc93ab4e1d8a98fbb5be0de451
Source dataset: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08389536B2

Reaction notes

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