4,4-Dimethyl-2-pyrrolidinone → HCID 52917192, compound

HRID 1942197Notes

Reaction equation

HRID 1942197 reaction equation
[C:1]1([C:7]#[C:8][C:9]2[CH:10]=[CH:11][C:12]([CH2:15]O)=[N:13][CH:14]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:17][C:18]1([CH3:24])[CH2:22][NH:21][C:20](=[O:23])[CH2:19]1>>[CH3:17][C:18]1([CH3:24])[CH2:22][N:21]([CH2:15][C:12]2[CH:11]=[CH:10][C:9]([C:8]#[C:7][C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)=[CH:14][N:13]=2)[C:20](=[O:23])[CH2:19]1

Participants

3

Reactant 2

HCID 6375934,4-Dimethyl-2-pyrrolidinoneHCID 57517077(5-Phenylethynyl-pyridin-2-yl)-methanol

Product 1

HCID 52917192HCID 52917192, compound

Procedure

The title compound, light brown oil, MS: m/e=305.2 (M+H+), can be prepared in accordance with the general method of example 31, step 2 from (5-phenylethynyl-pyridin-2-yl)-methanol (example 31, step 1) and 4,4-dimethyl-pyrrolidin-2-one.

Sources & evidence

ORD record
ord-b0ce5b089a84403e89c07ef4cd061364
Source dataset
uspto-grants-2013_03
Patent number
US08389536B2

Reaction notes

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