5,5-Dimethylpyrrolidin-2-one → HCID 52917112, compound

HRID 1942200Notes

Reaction equation

HRID 1942200 reaction equation
[C:1]1([C:7]#[C:8][C:9]2[CH:10]=[CH:11][C:12]([CH2:15]O)=[N:13][CH:14]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:17][C:18]1([CH3:24])[NH:22][C:21](=[O:23])[CH2:20][CH2:19]1>>[CH3:17][C:18]1([CH3:24])[N:22]([CH2:15][C:12]2[CH:11]=[CH:10][C:9]([C:8]#[C:7][C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)=[CH:14][N:13]=2)[C:21](=[O:23])[CH2:20][CH2:19]1

Participants

3

Reactant 2

HCID 111262105,5-Dimethylpyrrolidin-2-oneHCID 57517077(5-Phenylethynyl-pyridin-2-yl)-methanol

Product 1

HCID 52917112HCID 52917112, compound

Procedure

The title compound, light yellow oil, MS: m/e=305.2 (M+H+), can be prepared in accordance with the general method of example 31, step 2 from (5-phenylethynyl-pyridin-2-yl)-methanol (example 31, step 1) and 5,5-dimethyl-pyrrolidin-2-one.

Sources & evidence

ORD record
ord-133480cfabdb4c4c996f349700b4bc12
Source dataset
uspto-grants-2013_03
Patent number
US08389536B2

Reaction notes

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