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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1942203Generated: November 2, 2026

3-Methylpyrrolidin-2-one → rac-3-Methyl-1-(5-phenylethynyl-pyridin-2-ylmethyl)-pyrrolidin-2-one

https://huagongshe.com/reaction/1942203

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Methylpyrrolidin-2-oneHCID 102848—
Reactant(5-Phenylethynyl-pyridin-2-yl)-methanolHCID 57517077—
Productrac-3-Methyl-1-(5-phenylethynyl-pyridin-2-ylmethyl)-pyrrolidin-2-oneHCID 52917267—

Reaction Steps

The title compound, light yellow oil, MS: m/e=291.1 (M+H+), can be prepared in accordance with the general method of example 31, step 2 from (5-phenylethynyl-pyridin-2-yl)-methanol (example 31, step 1) and rac-3-methyl-pyrrolidin-2-one.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08389536B2
Source datasetuspto-grants-2013_03
ORD IDord-7a25940928d2416597bad3902a85eb2e
Source noteuspto-grants-2013_03