1-Methyltetrahydropyrimidin-2(1H)-one → 1-Methyl-3-(5-phenylethynyl-pyridin-2-ylmethyl)-tetrahydro-pyrimidin-2-one

HRID 1942204Notes

Reaction equation

HRID 1942204 reaction equation
[C:1]1([C:7]#[C:8][C:9]2[CH:10]=[CH:11][C:12]([CH2:15]O)=[N:13][CH:14]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:17][N:18]1[CH2:23][CH2:22][CH2:21][NH:20][C:19]1=[O:24]>>[CH3:17][N:18]1[CH2:23][CH2:22][CH2:21][N:20]([CH2:15][C:12]2[CH:11]=[CH:10][C:9]([C:8]#[C:7][C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)=[CH:14][N:13]=2)[C:19]1=[O:24]

Participants

3

Reactant 2

HCID 128677481-Methyltetrahydropyrimidin-2(1H)-oneHCID 57517077(5-Phenylethynyl-pyridin-2-yl)-methanol

Product 1

HCID 529171951-Methyl-3-(5-phenylethynyl-pyridin-2-ylmethyl)-tetrahydro-pyrimidin-2-one

Procedure

The title compound, light yellow oil, MS: m/e=306.2 (M+H+), can be prepared in accordance with the general method of example 31, step 2 from (5-phenylethynyl-pyridin-2-yl)-methanol (example 31, step 1) and 1-methyl-tetrahydro-pyrimidin-2-one.

Sources & evidence

ORD record
ord-0ad200a2aa144a62a3ab5952622f326d
Source dataset
uspto-grants-2013_03
Patent number
US08389536B2

Reaction notes

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