Phenylacetylene → rac-1-(5-Phenylethynyl-pyridin-2-yl)-ethanol

HRID 1942205Notes

Reaction equation

Br[C:2]1[CH:3]=[CH:4][C:5]([CH:8]([OH:10])[CH3:9])=[N:6][CH:7]=1.[C:11]1([C:17]#[CH:18])[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>>[C:11]1([C:17]#[C:18][C:2]2[CH:3]=[CH:4][C:5]([CH:8]([OH:10])[CH3:9])=[N:6][CH:7]=2)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Participants

Reactant 2

HCID 10821Phenylacetylene

HCID 426142881-(5-Bromopyridin-2-yl)ethanol

Product 1

HCID 57517078rac-1-(5-Phenylethynyl-pyridin-2-yl)-ethanol

Procedure

The title compound, brown solid, MS: m/e=224.2 (M+H+), can be prepared in accordance with the general method of example 31, step 1 from rac-1-(5-bromopyridin-2-yl)ethanol and phenylacetylene.

Sources & evidence

ORD record: ord-8fd5f4887038469598acb5ffbbec10f7
Source dataset: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08389536B2

Reaction notes

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